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Evidence is increasing that most addiction without exception is related to problems with the brain's reward center, particularly the mesolimbic system. This the main problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both once they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the those who go through it you ought to err along the side of caution and permit the FDA do its job and demand some study be done in order that the public understands the side effects and risks of the medications before we drive them. Keep in mind that drug companies come in business to earn money and that they would say everything to keep people on their own medications.

Researchers found that participants using this drug for any year, lost weight within a month and have kept the body weight off during the entire 56 weeks with the study. Contrave can be a combination of the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which can be made up of many active ingredient, that might make them more efficient and safer.

Combo-pilling may be the newest fad or better yet the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular will be the fact that since right now there are no long term prescription diet pills that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug also can raise blood pressure and heartrate, and really should not be used in people who have a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure and pulse rate and must 't be used in patients with uncontrolled high hypertension, in addition to by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients which has a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients to the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.


Approving a drug with this many potentially lethal unwanted side effects is inconsistent with all the mission statement with the FDA. The power from the drug manufacturing lobby is blatantly evident in the approval of countless drugs requiring 'post-marketing' studies which are clearly significant to overall drug safety within the US.